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The book aims to provide an overview of current knowledge regarding germ cell tumors. It deals with the clinical presentations, treatment modalities, the biology and genetics of germ cell tumors in children and adults. Most chapters are focused on testicular germ cell tumors whose incidence has been increasing in young males. Included are reviews on the pathogenesis, risk factors, diagnosis and treatment regimens applied to precursor, pre-invasive lesions as well as to seminomatous and non-seminomatous germ cell tumors of the testes. In addition, a review is included on the diagnosis and current management options for intracranial germ cell tumors in children. Authors have also contributed articles on the genetics and epigenetics of germ cell tumor development in humans and in the mouse model system. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of germ cell cancers.
Germ cells. --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Oncology
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Genetic Predisposition to Disease --- Germ-Line Mutation --- Neoplasms --- Colonic Neoplasms --- Urologic Neoplasms --- genetics --- genetics --- genetics
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Colorectal Neoplasms, Hereditary Nonpolyposis --- Germ-Line Mutation --- DNA-Binding Proteins --- genetics --- genetics --- genetics
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Chromosome Aberrations --- DNA Damage --- Germ Cells --- Mutagenicity Tests --- Mutation --- Mutations --- Polymorphism, Restriction Fragment Length --- Germ Line --- Gamete --- Gametes --- Germ-Line Cells --- Cell, Germ --- Cell, Germ-Line --- Cells, Germ --- Cells, Germ-Line --- Germ Cell --- Germ Line Cells --- Germ Lines --- Germ-Line Cell --- Injury, DNA --- DNA Injury --- Genotoxic Stress --- Stress, Genotoxic --- DNA Damages --- DNA Injuries --- Damage, DNA --- Damages, DNA --- Genotoxic Stresses --- Injuries, DNA --- Stresses, Genotoxic --- Pyrimidine Dimers --- Comet Assay --- DNA Repair Enzymes --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- Chromosomes --- Cytogenetics --- Genetics, Medical --- Cytogenetic Analysis --- methods --- abnormalities
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Germ cells --- Neuroptera --- -Ovaries --- Ovary --- Adnexa uteri --- Gonads --- Ovum --- Neuropterans --- Planipennia --- Insects --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Generative organs --- Ovaries
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This book focuses on the development and biology of germ cell and is edited by Ahmed RG, associate professor and Doctor of Developmental and Experimental Biology, Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. While many articles have appeared in journals on germ cell, this book provides you with a rare treat - an extensive and intensive study on it. It is one of a kind, offering important and valuable information about the biology of germ cell. This book covers the specification, regulation, and reprogramming of germ cell and germ line stem cells. This book provides important information about the new insight into germ cell signaling and the genotoxic in vitro studies in testicular germ cells. This book offers significant results about the origin, specification, and development of the female germ line in placental mammals and the germ cell tumors and their association with pregnancy.
Germ cells. --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Life Sciences --- Immunology and Microbiology --- Reproductive Immunology --- Pure Immunology
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The knowledge gained by studying germline stem cells, the source of human and animal reproduction, may find immediate application in preserving endangered wildlife, managing commercial livestock, overcoming fertility problems in humans, and treating testicular and ovary tumors. In Germline Stem Cells, leading experts explore the parameters that define germline stem cells and the mechanisms that regulate the cell behavior in order to better isolate, characterize and maintain them. Divided into two parts, the volume begins by providing protocols for germline stem cell identification and regulation in model organisms, and concludes with detailed chapters covering current techniques involving in vitro culture and the applications of the cells. Following the highly successful Methods in Molecular Biology™ series format, each chapter includes a brief introduction to the subject, a list of necessary equipment and reagents, step-by-step laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Germline Stem Cells is the perfect reference for scientists exploring this particular exciting and important subdivision in the fast-paced field of stem cell research.
Stem Cells. --- Stem cells. --- Cellules souches --- Stem cells --- Germ Cells --- Stem Cells --- Cells --- Genitalia --- Anatomy --- Urogenital System --- Cytology --- Biology --- Health & Biological Sciences --- Genitourinary System --- Genitourinary Systems --- System, Genitourinary --- System, Urogenital --- Systems, Genitourinary --- Systems, Urogenital --- Urogenital Systems --- Anatomies --- Accessory Sex Organs --- Genital Organs --- Sex Organs, Accessory --- Accessory Sex Organ --- Genital Organ --- Organ, Accessory Sex --- Organ, Genital --- Organs, Accessory Sex --- Organs, Genital --- Sex Organ, Accessory --- Cell --- Colony-Forming Unit --- Colony-Forming Units --- Mother Cells --- Progenitor Cells --- Cell, Mother --- Cell, Progenitor --- Cell, Stem --- Cells, Mother --- Cells, Progenitor --- Cells, Stem --- Colony Forming Unit --- Colony Forming Units --- Mother Cell --- Progenitor Cell --- Stem Cell --- Germ Line --- Gametes --- Germ-Line Cells --- Cell, Germ --- Cell, Germ-Line --- Cells, Germ --- Cells, Germ-Line --- Germ Cell --- Germ Line Cells --- Germ Lines --- Germ-Line Cell --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cytology. --- Medicine. --- Developmental biology. --- Human genetics. --- Cell Biology. --- Molecular Medicine. --- Developmental Biology. --- Human Genetics. --- Health Workforce --- Cell biology --- Cellular biology --- Cytologists --- Development (Biology) --- Growth --- Ontogeny --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology
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Reproduction --- Molecular biology --- Molecular genetics --- Embryology --- Biologie moléculaire --- Génétique moléculaire --- Embryologie --- Embryology. --- Molecular biology. --- Molecular genetics. --- Reproduction. --- Amphimixis --- Generation --- Pangenesis --- Procreation --- Molecular biochemistry --- Molecular biophysics --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Development --- Biology --- Life (Biology) --- Physiology --- Sex (Biology) --- Generative organs --- Theriogenology --- Genetics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Developmental biology --- Morphology (Animals) --- Embryos --- Embryonic and Fetal Development. --- Germ Cells --- growth & development. --- Human Reproductive Index --- Human Reproductive Indexes --- Reproductive Period --- Human Reproductive Indices --- Index, Human Reproductive --- Indexes, Human Reproductive --- Indices, Human Reproductive --- Period, Reproductive --- Periods, Reproductive --- Reproductive Index, Human --- Reproductive Indices, Human --- Reproductive Periods --- Prenatal Programming --- Embryo and Fetal Development --- Programming, Prenatal --- Developmental Biology --- Beginning of Human Life --- Embryonic Development. --- Fetal Development. --- Germ Cells. --- Germ Line --- Gametes --- Germ-Line Cells --- Cell, Germ --- Cell, Germ-Line --- Cells, Germ --- Cells, Germ-Line --- Germ Cell --- Germ Line Cells --- Germ Lines --- Germ-Line Cell --- Fetal Growth --- Fetal Programming --- Development, Fetal --- Fetal Programmings --- Growth, Fetal --- Fetus --- Embryonic Programming --- Post-implantation Embryo Development --- Postnidation Embryo Development --- Postnidation Embryo Development, Animal --- Pre-implantation Embryo Development --- Prenidation Embryo Development, Animal --- Embryo Development --- Postimplantation Embryo Development --- Preimplantation Embryo Development --- Development, Embryo --- Development, Postnidation Embryo --- Embryo Development, Post-implantation --- Embryo Development, Postimplantation --- Embryo Development, Postnidation --- Embryo Development, Pre-implantation --- Embryo Development, Preimplantation --- Embryonic Developments --- Embryonic Programmings --- Post implantation Embryo Development --- Pre implantation Embryo Development --- Embryo, Mammalian --- Embryo, Nonmammalian --- growth & development
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Immunology. Immunopathology --- Zoohistology. Zoocytology --- Antibody diversity --- Antibody Diversity --- 616.9 --- Diversity, Antibody --- Germ line theory --- Immunoglobulin diversity --- Somatic mutation theory --- Clonal selection theory --- Immunogenetics --- Gene rearrangement --- Immunoglobulins --- Immunospecificity --- Communicable diseases. Infectious and contagious diseases, fevers --- 616.9 Communicable diseases. Infectious and contagious diseases, fevers
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Germ cell tumors are relatively rare compared with other malignancies, and compilations of knowledge that encompass the entire spectrum of the disease are lacking. This textbook, written by the foremost authorities in the field, rectifies the situation by discussing in depth a broad range of topics, including biology, epidemiology, pathology, treatment, and late effects. Bearing in mind that germ cell tumors are most prevalent in the adolescent and young adult age group, causes of disease and treatment approaches in pediatric and adult patients are compared and contrasted. By spanning the entire life course, from prenatal origins of disease through to treatment in adults and late effects of treatment, the editors have produced a book that will be of interest to both pediatric and adult oncologists.
Tumors in children --- Germ cells --- Treatment. --- Tumors --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Pediatric oncology --- Medicine. --- Oncology. --- Pediatrics. --- Medicine & Public Health. --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases --- Health and hygiene --- Cells --- Germplasm resources --- Oncology .
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